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KMID : 1033620110380010047
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Clinical and Experimental Reproductive Medicine
2011 Volume.38 No. 1 p.47 ~ p.52
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Predictive value of sperm motility characteristics assessed by computer-assisted sperm analysis in intrauterine insemination with superovulation in couples with unexplained infertility
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Youn Joung-Sub
Cha Sun-Hwa
Park Chan-Woo
Yang Kwang-Moon
Kim Jin-Yeong
Koong Mi-Kyoung
Kang Inn-Soo
Song In-Ok
Han Sang-Chul
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Abstract
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Objective: To determine whether characteristics of sperm motility obtained by computer-assisted sperm analysis (CASA) could predict pregnancy after intrauterine insemination (IUI) in couples with unexplained infertility.
Methods: Three hundred eighty-three cycles of intrauterine insemination with superovulation were retrospectively analyzed. Semen analysis was performed with CASA before and after swim-up and the parameters were compared between pregnant and non-pregnant women.
Results: The pregnancy rate per cycle was 14.1%. Pregnant and non-pregnant women were comparable in terms of age, infertility duration, the number of dominant follicles. While sperm concentration, motility, and parameters such as average path velocity (VAP) and percentage rapid (RAPID) before semen preparation were significantly different between the pregnancy and non-pregnancy groups, there were no differences in sperm parameters when comparing the two groups after preparation. Using a receiver operating characteristic curve to measure sensitivity and specificity, the optimal threshold value for the predictors of pregnancy was revealed to be a concentration of ≥111×106/mL, a motility of ≥51.4%, and RAPID ≥30.1% before preparation for IUI.
Conclusion: Sperm parameters including concentration, motility, and RAPID before sperm preparation could have predictive value for pregnancy outcome after intrauterine insemination with superovulation in couples with unexplained infertility, and would be helpful when counseling patients before they make the decision to proceed with IVF/ICSI-ET.
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KEYWORD
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Insemination, Artificial, Infertility, Semen Analysis, Image Processing, Computer-assisted, Sperm Motility, Human
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